Guangchen Ji Selected Research

N- cyclobutyl- 6- ((3- fluorophenyl)ethynyl)nicotinamide

1/2016	Rescue of Impaired mGluR5-Driven Endocannabinoid Signaling Restores Prefrontal Cortical Output to Inhibit Pain in Arthritic Rats.
2/2014	CB1 augments mGluR5 function in medial prefrontal cortical neurons to inhibit amygdala hyperactivity in an arthritis pain model.

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Guangchen Ji Research Topics

Disease

31	Pain (Aches) 01/2022 - 08/2004
12	Arthritis (Polyarthritis) 09/2019 - 06/2007
6	Neuralgia (Stump Neuralgia) 10/2021 - 01/2017
2	Hypersensitivity (Allergy) 01/2022 - 04/2019
2	Chronic Pain 10/2021 - 01/2020
2	Hyperalgesia 04/2019 - 07/2015
1	Neuroinflammatory Diseases 01/2022
1	Encephalomyelitis (Myeloencephalitis) 01/2022
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2022
1	Multiple Sclerosis 01/2022
1	Parkinson Disease (Parkinson's Disease) 01/2022
1	Acute Pain 04/2019
1	Anxiety Disorders (Anxiety Disorder) 01/2017
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 08/2015
1	Visceral Pain 05/2015

Drug/Important Bio-Agent (IBA)

10	CarrageenanIBA 12/2017 - 06/2007
10	KaolinIBA 12/2017 - 06/2007
6	Corticotropin-Releasing HormoneIBA 01/2022 - 03/2008
5	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2016 - 09/2008
4	NeuropeptidesIBA 01/2020 - 10/2013
3	kappa Opioid Receptors (kappa Opioid Receptor)IBA 01/2022 - 04/2019
3	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2015 - 07/2010
2	norbinaltorphimineIBA 01/2022 - 04/2019
2	CRF receptor type 1IBA 09/2019 - 06/2007
2	Serotonin ReceptorsIBA 09/2019 - 01/2017
2	Riluzole FDA LinkGeneric 01/2018 - 08/2015
2	CalciumIBA 01/2018 - 08/2015
2	PotassiumIBA 01/2018 - 08/2015
2	EndocannabinoidsIBA 01/2016 - 08/2009
2	N- cyclobutyl- 6- ((3- fluorophenyl)ethynyl)nicotinamideIBA 01/2016 - 02/2014
2	Pharmaceutical PreparationsIBA 08/2015 - 03/2007
2	metabotropic glutamate receptor type 1IBA 11/2011 - 07/2010
2	3,4-dihydroxyphenylglycolIBA 11/2011 - 01/2011
2	2- methyl- 4- (N- propyl- N- cycloproanemethylamino)- 5- chloro- 6- (2,4,6- trichloranilino)pyrimidineIBA 06/2007 - 06/2007
1	ginger extractIBA 01/2022
1	Mitochondrial DNA (mtDNA)IBA 01/2022
1	Dopamine (Intropin)FDA LinkGeneric 01/2022
1	Urea (Carbamide)FDA LinkGeneric 01/2022
1	Dopamine Agents (Dopaminergic Agents)IBA 01/2022
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2022
1	cerebellinIBA 10/2021
1	Glutamic Acid (Glutamate)FDA Link 10/2021
1	Proteins (Proteins, Gene)FDA Link 10/2021
1	AMPA Receptors (AMPA Receptor)IBA 10/2021
1	Serotonin (5 Hydroxytryptamine)IBA 09/2019
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 04/2019
1	Opioid Analgesics (Opioids)IBA 04/2019
1	Dynorphins (Dynorphin)IBA 04/2019
1	Gabapentin (Neurontin)FDA LinkGeneric 04/2019
1	salicylhydroxamic acid (SHAM)IBA 01/2018
1	monomethyl fumarateIBA 12/2017
1	5-HT2C Serotonin ReceptorIBA 01/2017
1	Metabotropic Glutamate 5 ReceptorIBA 01/2016
1	Calcitonin Gene-Related PeptideIBA 01/2016
1	Oxytocin Receptors (Oxytocin Receptor)IBA 01/2016
1	Vasopressins (Vasopressin)IBA 01/2016
1	GTP-Binding Proteins (G-Protein)IBA 01/2016
1	Arginine Vasopressin (Argipressin)IBA 01/2016
1	Large-Conductance Calcium-Activated Potassium Channels (Maxi-K Channels)IBA 08/2015
1	pyrazolanthroneIBA 07/2015
1	Etanercept (Enbrel)FDA Link 07/2015
1	Biological ProductsIBA 07/2015
1	ZymosanIBA 05/2015
1	Anti-Anxiety Agents (Anxiolytics)IBA 05/2014
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 02/2014
1	GABA-A Receptor AntagonistsIBA 11/2011
1	GABA-A Receptors (GABA(A) Receptor)IBA 11/2011
1	BicucullineIBA 11/2011
1	AcidsIBA 11/2011
1	IodidesIBA 11/2011
1	pyridineIBA 11/2011
1	Superoxides (Superoxide)IBA 01/2011
1	Protein Kinases (Protein Kinase)IBA 01/2011
1	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 10/2009
1	protein kinase modulatorIBA 10/2009
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 04/2009
1	metabotropic glutamate receptor 8IBA 09/2008
1	metabotropic glutamate receptor 7IBA 09/2008
1	Hormones (Hormone)IBA 03/2008
1	Neurotransmitter Agents (Neurotransmitter)IBA 03/2008
1	Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)IBA 11/2007
1	CRF receptor type 2IBA 06/2007
1	astressinIBA 06/2007
1	Somatostatin Receptors (Somatostatin Receptor)IBA 08/2004

Therapy/Procedure

5	Intra-Articular Injections 11/2011 - 06/2007
4	Ligation 01/2022 - 01/2017
2	Therapeutics 10/2021 - 04/2019
1	Injections 11/2011